This study indicates, however, that ultrasound variables have an independent prognostic role beyond the ESMO risk classification and that the combination of ultrasound and p53 status, often obtained on routine histopathology assessment, can identify a large group of women (48%) at very low risk of tumor recurrence or progression (1.8%) in whom neither sentinel‐node biopsy nor adjuvant treatment may be considered necessary. Here, TP53 is linked to neoplasm.