The Cancer Genome Atlas (TCGA) Research Network developed a genomic classification of endometrial cancer into four prognostic subgroups (polymerase‐ε (POLE) ultramutated, microsatellite instability hypermutated, copy number low and copy number high7), which, however, requires costly and complex methodologies, making the TCGA classification not yet fit for clinical use. The gene discussed is POLE; the disease is endometrial cancer.