Apart from amyloid pathology and neuroinflammation, LC degeneration has been shown to be strongly related to tau pathology; as abovementioned, the first signs of AD-related pathological alterations (years before the first clinical symptoms and the occurrence of amyloid plaques) occur in LC and are represented by the accumulation of pTAU (also denominated “pre-tangle Tau”) [8]. The gene discussed is MAPT; the disease is Alzheimer disease.