In the infarcted area, the mRNA expression levels of various fibrosis-related genes including transforming growth factor (TGF) β1, TGFβ2, collagen (COL) I, COLIII, and connective tissue growth factor (CTGF) were significantly increased in the Sed-MI and Ex-MI groups compared with the Sham groups (p < 0.001). The gene discussed is CCN2; the disease is myocardial infarction.