In summary, FN1, COL1A1, COL1A2, COL3A1, BGN, COL5A2, THBS2, SPARC, FBN1, COL5A1, SPP1, COL6A3, TIMP1, SERPINH1, COL12A1, RUNX2, BMP1, COL10A1, NID2, and COL8A1 might be hub genes of GC. This evidence concerns the gene COL6A3 and gastric cancer.