CXCR3 and CCR6 were found to be upregulated on CD4+ Tfh cells in lesion tissues of IgG4-RD patients [4], suggesting that increased Tfh in IgG4-RD might be CXCR3+ Tfh and CCR6+ Tfh cells. This evidence concerns the gene CXCR3 and immunoglobulin G4-related sclerosing disease.