CD4 and immunoglobulin G4-related sclerosing disease: Interestingly, the absolute numbers (per μL) of circulating Th2 plus naïve CD4 cells were significantly lower in remission IgG4-RD patients than in active patients and HC (197.9 cells/μL versus 400.9 cells/μL and 374.6 cells/μL; P = 0.0264 and P = 0.0474, respectively).