In our analysis, we identified proteins related to premature retinopathy and macular degeneration, such as pigment epithelium-derived factor (SERPINF1), transforming growth factor beta-1 proprotein (TGFB1), fibrinogen alpha chain (FGA), mannan-binding lectin serine protease 1 (MASP1), moesin (MSN), and vitronectin (VTN), upregulated in the ZIKV group, suggesting the possibility of developing these complications. The gene discussed is PRSS1; the disease is retinopathy of prematurity.