In at least six cancer cell lines, it has shown superior HDACi activity over Ramidopsine (approved HDACi). Burkholdacs A presents more affinity for HDAC1 and was determined to be superior than B with respect to its HDAC1 inhibitory activity and isoform selectivity toward HDAC1 over HDAC6 and antiproliferative activity. The gene discussed is HDAC1; the disease is cancer.