The results showed that tumor size (HR = 2.21, 95% CI, 1.30–3.75), microvascular invasion (HR = 2.65, 95% CI, 1.63–4.32), tumor differentiation (HR = 1.82, 95% CI, 1.14–2.90), Ki67 (%) (HR = 1.99, 95% CI, 1.12–3.54), AFP (HR = 2.41, 95% CI, 1.38–4.19), CA125 (HR = 1.13, 95% CI, 1.55–4.23), and HBsAg status (HR = 2.15, 95% CI, 1.02–4.5) were unfavorable prognostic parameters for OS in SLHCC patients (Table 2). Here, MKI67 is linked to neoplasm.