ABCB6 and cancer: But in addition to the adverse effects of this drug (nausea, vomiting and toxic effects on different organs) (12), there are various routes by which the cancer can develop resistance to cisplatin’s anticarcinogenic action on OSCC: reduced formation of cisplatin-DNA adducts (which causes a reduction in cytotoxicity against carcinogenic cells) and generation of subpopulations of CSCs capable of ABC expression (drug transporter proteins) that may be responsible for OSCC resistance to cisplatin (23–25).