The DisGeNET database was used to select the first 20 reported osteosarcoma-related genes: CHEK2, TP53, RB1, VEGFA, EGFR, RUNX2, MDM2, MMP2, MET, DHFR, TNFRSF11A, JUN, RFC1, RECQL4, GSTP1, NR1I2, TOPORS, CYP3A4, MYC, and KCNH1. The gene discussed is RUNX2; the disease is osteosarcoma.