Other studies have revealed that MTDH plays an important regulatory role in tumor proliferation, differentiation, apoptosis, migration, invasion, and drug resistance (39–41) via the Ha-ras, PI3K/Akt, NF-kappa B, and Wnt/beta-catenin signaling pathways (38, 41, 42). This evidence concerns the gene CTNNB1 and neoplasm.