However, the test equipment resulted in a high false-negative test detecting SARS-CoV-2 IgM antibodies, especially in acute phase.29 Oliveira et al explained that the high spread of COVID-19 through community transmission made the tool not tested for people suspected of being infected with COVID-19 so that test kits were prioritized for health workers and police.24,26 It could affect the failure of efforts to prevent transmission in Brazil, resulting in a dramatic increase in mortality. The gene discussed is CD40LG; the disease is COVID-19.