NOTCH3 and cancer: Also, the anti-cancer effect of silencing DLGAP5 has confirmed in other vitro cell experiments, which may also be related to the fact that DLGAP5 can weaken the ubiquitination and proteasome degradation of p53, or become a direct target gene of the NOTCH3 signaling pathway  (Chen et al., 2012; Kuo et al., 2012).