The reported negative correlations between serotonin and inflammatory cytokines (IL-12 and IL-6), obesity (leptin and BMI), antioxidant status (GSH), and dyslipidemia-related markers (cholesterol, triglycerides, and total/HDL), respectively, can find support in the recent work of van Galen et al. [31], who highlighted that the neuroinflammation and dyslipidemia complications of obesity may be associated with decreased serotonergic signaling. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.