In line with our previous observations regarding the inhibition of DC subset function in HBV patients,30, 35 we demonstrate here that HBsAg binds to cDC2s, cDC1s, and pDCs from HD in a CLR‐ and glycosylation‐dependent manner, and inhibits their functional response to specific TLR triggering. This evidence concerns the gene DCLK3 and Huntington disease.