INS and Hyperglycemia: In comparisons of pair feeding (calorie restriction), insulin, SGLT2‐inhibitor phloridzin, and insulin sensitizer rosiglitazone in db/db mice, only pair feeding successfully suppressed markers of β‐cell dedifferentiation (Ishida et al., 2017), suggesting either alleviation of hyperglycemia or reduction of the secretory workload on β cells will not reverse β‐cell dedifferentiation.