Although the upregulated patterns of NPY, NGF, and NF160 expression by CCS‐HE did not show a precise relationship of growth and decline, attenuation of CCS‐HE‐induced NGF and NF160 expression by NPY depletion indicated that CCS‐HE‐induced NPY expression was an upstream event of NGF and NF160 expression in the process of neurite outgrowth by CCS‐HE. This evidence concerns the gene NPY and hereditary elliptocytosis.