Recently, it was shown that the NLRP3 inflammasome, which is a complex that contains NLRP3, ASC, and caspase-1, plays an important role in colitis and colitis-associated colon cancer (CAC) [5] and is also known as a potential target for the prevention of colitis and CAC [4]. Here, NLRP3 is linked to malignant colon neoplasm.