CYBB and neoplasm: These results were confirmed and extended by Van der Weyden et al. showing that hematogenous metastasis was markedly reduced in mice genetically depleted of any of the major NOX2 subunits (Cyba, Cybb, Ncf1, Ncf2, and Ncf4) and that tumor tissues of NOX2-deficient mice showed a marked increase of antineoplastic lymphocytes [141].