CYBB and melanoma: While these antitumor effects of HDC are likely pleiotropic, it is noteworthy that beneficial effects of treatment with HDC in murine melanoma, lymphoma, and mammary cancer were only observed in NOX2-sufficient mice [32, 35, 37, 148] and that HDC only inhibited growth of NOX2+ and not NOX2− leukemic cells in a xenograft setting [35].