MAPT and Alzheimer disease: Indeed, chromatin immunoprecipitation with deep sequencing shows that REST represses proapoptotic genes, e.g., FAS, FAS-associated death domain protein (FADD), TNF receptor-associated death domain protein (TRDD), Bcl-2-associated X protein (BAX), and cytochrome c, as well as AD pathology-associated genes, e.g., presenilin-2 (PSEN2) and presenilin enhancer 2 (PSENEN) implicated in Aβ generation and MAPK implicated in tau phosphorylation.