MAPT and Alzheimer disease: Conversely, the intrahippocampal delivery of a microRNA-146a specific inhibitor (antagomir) into transgenic mice with five familial AD mutations (5xFAD mice) showed enhanced hippocampal levels of rho-associated, coiled-coil containing protein kinase 1 (ROCK1) protein and repressed tau hyperphosphorylation, partly restoring the memory function in the 5xFAD mice [102].