It was preliminarily confirmed that PS could inhibit the release and expression of inflammatory factors such as TGF-β1, TNF-α, and IL-1β by regulating the TGF-β1/p38MAPK/NF-κB signaling pathway, to improve renal tissue injury, inflammatory factor infiltration, and renal fibrosis in GN rats. The gene discussed is NFKB1; the disease is ganglioneuroma.