Thus, Ramos and CCRF-CEM cells were treated with the different peptides and the combination of the cell-permeable Bak BH3 peptide (PETK) plus the cell-permeable Bax BH3 peptide (PEX), in the presence of a subtoxic dose of vincristine, a commonly used drug in the management of hematologic malignancies [50]. The gene discussed is BAX; the disease is hematologic disorder.