Overall, our findings have shown the ability of the Bak BH3 peptide coupled with the Antennapedia fusogenic peptide (cell-permeable Bak BH3 peptide) to restore apoptosis and induce chemosensitization in acute lymphoblastic leukemia and non-Hodgkin's lymphoma cell lines, which may be further enhanced with the addition of the cell-permeable Bax BH3 peptide. Here, BAK1 is linked to acute lymphoblastic leukemia.