An analysis of the data and signaling pathways available in the literature suggests two mechanisms for the participation of peroxisome proliferator-activated receptors in the formation of anxiety: (1) expression of cytokines and neuroinflammation and (2) regulation of the expression of peptidases, the targets of which are neuropeptides associated with anxiety (CCK-4 in the first place). Here, PTK7 is linked to Anxiety.