Although the association between T1D and PCM in literature is not strong, both are considered highly undiagnosed/underreported diseases (1, 8), and our studies show an important rise in susceptibility for a more severe case of PCM in T1D mice, possibly resulting from an overall reduced protection against the pathological agent (16), and that insulin partially restored cellular inflammation indexes. Here, INS is linked to paracoccidioidomycosis.