show that high glucose levels appear to modify macrophage behavior, affecting different aspects of diabetic (impaired phagocytic ability, reduced production of reactive hydrogen species, and reduced expressions of TLR-4 on the cell surface) and healthy bone marrow-derived macrophages under the same LPS stimulus, hypothesizing that hyperglycemia leaves a glucose legacy, altering the basal steady state of macrophages (32). This evidence concerns the gene TLR4 and Hyperglycemia.