In the present study, we first confirmed that our mouse model of HDM-induced asthma not only exhibited the allergic asthma features of eosinophilia, Th2 response, and allergen-specific IgE production (26) but also key features of severe asthma, such as neutrophilia, Th17 response, and low steroid sensitivity (27). The gene discussed is IGHE; the disease is Increased total eosinophil count.