On the other hand, studies performed in four kindreds from Newfoundland demonstrated that a single nonsense mutation in the MEN1 gene (R460X) was predominantly associated with prolactinomas, carcinoids and parathyroid tumors (167, 181–183), though the same mutation has been described in other MEN1 cases with milder MEN1 clinical features (26, 30, 137, 164, 184–188). The gene discussed is MEN1; the disease is carcinoid tumor.