CXCL10, a chemokine elevated in various central nervous system (CNS) pathologies like Alzheimer's disease (58), multiple sclerosis (59), and Rasmussen encephalitis (60), has been shown to elicit elevated neuronal excitability after acute (61) and chronic exposure (62). The gene discussed is CXCL10; the disease is early-onset autosomal dominant Alzheimer disease.