Given that clinical features of COVID-19 appear to be widely determined by the cells and tissues with co-expression of ACE2 and TMPRSS2 in their constituent cells, it is fitting to evaluate the activity of the virus on those male and female reproductive cells in which there is a co-expression of the two proteins, and if SARS-CoV-2 could consequently have a negative impact on fertility. This evidence concerns the gene TMPRSS2 and COVID-19.