Upon exposure of Man12 HLCs to BPF we observed an increase in cell identity transcription factors including TBP, FOXA1, FOXA2 but also MEF2, a protein that promotes epithelial to mesenchymal transition during the onset of hepatocellular carcinoma (Yu et al., 2014[55]). This evidence concerns the gene FOXA2 and hepatocellular carcinoma.