CTCF and hepatocellular carcinoma: In response to BPS, we observed the decreased representation of the CCCTC-binding factor (CTCF), a key regulator of hepatocyte proliferation in response to injury (Wang et al., 2020[48]) and NFATC2, which is enriched in chromatin-accessible regions of genes involved in the development of liver steatosis and hepatocellular carcinoma (Dechassa et al., 2018[7]).