Therefore, the most promising pharmacogenes, relevant for therapy response in COVID-19 patients treated with chloroquine, hydroxychloroquine, azithro mycin or lopinavir and ritonavir are SLCO1B1, ABCB1, ABCC1, ABCC2, (transporter encoders), UGT1A1, UGT1A3, UGT1A7, CYP1A1, CYP2C8, CYP2D6, CYP3A4, CYP3A5, (metabolizer encoders), APOE and APOC3 (lipoprotein encoders) and G6PD. This evidence concerns the gene CYP2C8 and COVID-19.