We have shown that rather frequent PGx markers, ABCB1 rs1045642 and ABCB1 rs2032582 (AAF around 50%), could be relevant for reduced clearance of azithromycin, lopinavir and ritonavir drugs and UGT1A7 rs17868323 (AAF 66.2%) for hyperbilirubinemia in ritonavir treated COVID-19 patients in Serbia. This evidence concerns the gene UGT1A7 and Hyperbilirubinemia.