GDF15 and type 2 diabetes mellitus: Utilizing ROC curve for value of GDF-15 and risk of ACS among T2DM patients, it was seen that the greatest increase in risk of ACS was seen at serum GDF-15 concentration more than 1075.78 ng/L (AUC = 0.727, sensitivity of 69%, and specificity of 69%, LR = 2.23, P < 0.001) (Figure 1).