In contrast, concentrations of sclerostin were significantly higher in patients with hyperthyroidism than in control subjects (377.49±197.44 pg/mL vs 145.91±81.36 pg/mL) (Independent samples t-test, p=0.008) and patients with subclinical hyperthyroidism (Mann Whitney test, p=0.013). Here, SOST is linked to hyperthyroidism.