BGLAP and hyperthyroidism: In an analysis of osteocalcin concentrations in patients with abnormal thyroid function (hyperthyroidism, hypothyroidism and subacute thyroiditis), Kojima et al. [33] found a positive correlation with thyroxine and triiodothyronine levels, suggesting that osteoblast activity was increased in hyperthyroidism and decreased in hypothyroidism.