Hyperthyroid patients had higher concentrations of osteocalcin and beta-crosslaps in relation to patients with hypothyroidism (p=0.018 for osteocalcin; p=0.030 for beta-crosslaps), patients with subclinical hyperthyroidism (p=0.044 for osteocalcin; p=0.005 for beta-crosslaps) and control subjects (p=0.034 for osteocalcin; p=0.041 for beta-cross-laps). The gene discussed is BGLAP; the disease is hypothyroidism.