An infectious disease (35.4%) was the most frequent extra-cardiac cause of cTnI elevation (>URL, i.e., 34 ng/L), followed by neurological disorders (21.3%), respiratory diseases (12.4%), gastrointestinal disorders (8.9%), metabolic disturbances (6.4%), CRF (4.5%), bleeding (2.5%) and malignancies (2.5%). Here, TNNI3 is linked to nervous system disorder.