Overall, increased HS-cTnI values (>URL; i.e., >34 ng/L in men and >16 ng/L women, respectively) were found in 114/918 (12.4%) patients out of the entire cohort, and the leading underlying pathologies were infectious diseases and/or sepsis (27%), traumas (22%), respiratory diseases (10%), gastrointestinal disorders (6%), CRF (5%) and neurological diseases (3%). The gene discussed is TNNI3; the disease is nervous system disorder.