Further studies are required to elucidate if the novel association of HLA-B*07:05 allele is attributed to HLA-Baa-R156 or other rare functional variants such as rs2596540 at MICA and rs77803816 in HCP5. HCP5 is a regulatory lncRNA 100 kb centromeric from HLA-B involved in adaptive and innate immune responses, multiple autoimmune and viral-associated diseases such as HIV-1-associated AIDS and HCV-associated hepatocellular carcinoma49–53. This evidence concerns the gene HCP5 and AIDS.