HLA-B and nasopharyngeal carcinoma: Among the three independent signals related to HLA-B locus, the most interesting is the novel independent protective signal, rs2523589 (chr6:31,359,557, hg38) located ~2.4 kb upstream of HLA-B (P = 1.77 × 10−36, OR = 0.59), as it provides mechanistic insights for NPC genetic epidemiology.