Similarly, only one of five patients with MYC-expressing DLBCL responded to treatment with birabresib.28 BET inhibition may modulate other pathways related to anti-apoptotic protein expression, nuclear factor-κB signalling, E2F-mediated gene expression or other super-enhancers of additional critical B-cell transcriptional factors that may also contribute to clinical activity.15 The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.