Of note, DLBCLs with c-MYC and BCL-2 or BCL-6 translocation, so-called double-hit lymphomas, as well as those with high surface expression of MYC and BCL-2 (double-expressor) are recognised to have poor prognosis,22,38,39 even if they do not necessarily display a coordinated set of other genetic disturbances.40 Both responding patients in this study had tumours with c-MYC expression, one of which was a double-expressor. The gene discussed is BCL2; the disease is lymphoma.