MYC and metastatic neoplasm: The primary and metastatic tumours demonstrated the somatic mutations FBXW7 Q242H, FBXW7 S582L as well as KDM6A S763I and PIK3C2B Q877_W878K, suggesting the possibility of bi-allelic FBXW7 loss resulting in a high level of MYC protein expression, which was documented in the metastatic tumour (Supplementary Fig. S4A).