Multiple variants in proximity to 47 genes linked to congenital cataract were nominally associated with ARNC in our analysis (Fig. 2 and Supplementary Data 2), but only 5 survived correction for multiple testing (α = 5 × 10−4) in BFSP1 (β = 0.08; P = 3.5 × 10−5), LIM2 (β = 0.04; P = 1.4 × 10−4), MIP (β = 0.02; P = 3.4 × 10−4), TFAP2A (β = 0.05; P = 3.7 × 10−4) and CHMP4B (β = 0.08; P = 3.8 × 10−4). This evidence concerns the gene BFSP1 and cataract.