We found that a high expression level of PAI-1 in the tumor stroma was closely correlated with depth of tumor invasion (p < 0.001), high expression levels of αSMA (p < 0.001) and FAP (p < 0.001), and high numbers of infiltrating CD204+ macrophages (p = 0.002) (Table 2). This evidence concerns the gene SERPINE1 and neoplasm.