Connective tissue disorders genes FBN2, ADAMTS17, and SMAD3 affected by fine-mapped variants, as well as lower enrichment of regions active in cornea epithelial cells compared to that in fibroblastic cells lines, and improved enrichment when OCR shared with hTCEpi are removed from the hTK dataset, also support this notion. This evidence concerns the gene SMAD3 and connective tissue disorder.