Thus, introduction of miR-375 antagomirs into MCC cells, reduced their impact on transferring miR-375 to fibroblasts by either DC or TC conditions, which was associated with reduced induction of α-SMA protein and ACTA2, CXCL2 and IL1B mRNA in the cocultured fibroblasts; the change in protein and mRNA expression was more pronounced under DC (Fig. 5a–f) as compared to TC conditions (Supplementary Fig. S5a–f). The gene discussed is ACTA2; the disease is Merkel cell skin cancer.