The observed effects of the miR-375 knockdown in MCC cells on their capacity of CAF polarization was directly explained by their reduced impact on RBPJ and TP53 mRNA and protein in fibroblasts after coculture which was again more evident under DC (Fig. 5g–j) than TC conditions (Supplementary Fig. S5g–j). Here, RBPJ is linked to Merkel cell skin cancer.