The LC domain also exerts a prion-like function to mediate the amyloid aggregation of hnRNPA1, which is causative to neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP)7,12,15–17, and enhanced by inheritable mutations12,15. The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.