MAPT and early-onset autosomal dominant Alzheimer disease: In addition to Drosophila α-synucleinopathy models15,24, we have previously described models relevant to Alzheimer’s disease and related tauopathies in Drosophila. When we express wild-type or familial tauopathy mutant forms of human tau in flies we recapitulate key features of the disorders including behavioral deficits, neurodegeneration, and protein aggregation25–27.