In addition to Drosophila α-synucleinopathy models15,24, we have previously described models relevant to Alzheimer’s disease and related tauopathies in Drosophila. When we express wild-type or familial tauopathy mutant forms of human tau in flies we recapitulate key features of the disorders including behavioral deficits, neurodegeneration, and protein aggregation25–27. This evidence concerns the gene MAPT and synucleinopathy.