GPX4 and pancreatitis: In contrast, the administration of liproxstatin-1, a widely used ferroptosis inhibitor through its strong antioxidant activity11, protected against cerulean- or l-arginine-induced pancreatitis, especially in the presence of a high-iron diet or Gpx4 depletion (Fig. 1a–e and Supplementary Fig. 1a–e).