Notably, several factors that were increased more than 2-fold, including SCF-1, VEGF, osteopontin, MCP-2/3, IL-3, IL-12, and IFN-γ (Fig. 1c), have all been implicated in various aspects of cancer development, and thus represent a unique signature of the secretome of BTG3-depleted normal human fibroblasts. This evidence concerns the gene VEGFA and cancer.