To determine whether overexpression of δ-secretase is sufficient to trigger AD-like pathologies in hAPP/hMAPT double-transgenic mice, we injected the AAV9-AEP virus into the hippocampus of 2 month-old wild-types, hAPP, hMAPT and hAPP/hMAPT transgenic mice. This evidence concerns the gene LGMN and Alzheimer disease.