ZFAND3 and neoplasm: However, in contrast to cytoplasmic ZFAND3 staining (Fig. 2g), we found that both the staining intensity and the ratio of nuclear/cytoplasmic ZFAND3 staining were increased in peripheral tumor cells compared to central cells, indicating that the relative fraction of tumor cells with nuclear ZFAND3 is higher in the tumor periphery, and that nuclear ZFAND3 is expressed to a higher extent in these cells (Fig. 2h, i).