Among these DEGs, we selected genes reportedly linked to GBM cell invasion including COL6A2 (alpha-2 subunit of type VI collagen), EGFR (epidermal growth factor receptor), FN1 (fibronectin 1), NRCAM (neuronal cell adhesion molecule) and NRP1 (neuropilin 1), and confirmed their downregulation upon ZFAND3 KD (Fig. 6d–h), thus supporting a role for ZFAND3 in transcriptional regulation. The gene discussed is COL6A2; the disease is glioblastoma.