Histo-pathological analysis showed characteristics of inflammatory bowel disease with moderately reduced colon length, serious colonic wall thickening, increased infiltration of macrophages (F4/80+), neutrophil (GR-1) and hyperproliferation of colon epithelial cells (IECs) (Ki67+) in colon, but ileum was less affected (Fig. 4f, g and Supplementary Fig. 5b). The gene discussed is MKI67; the disease is inflammatory bowel disease.