In this study, we used CLIP to identify an aberrant intramolecular bipartite interaction between ALS-associated FUS and the U1 snRNA, where the zinc-finger domain contacts a GGU motif in the Sm site and interferes with cytoplasmic U1 snRNP assembly in vitro and in a mouse model of FUS-linked ALS (Fig. 6b). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.