On the other hand, given the evidence that lnc-SCARNA10 promotes the expression of TGF-β components, thus activating TGF-β signaling, which could subsequently upregulates the level of ATF3, we proposed that TGF-β/ATF3/lnc-SCARNA10 form a positive feedback loop that activates HSCs, contributing to liver fibrosis. This evidence concerns the gene ATF3 and Hepatic fibrosis.