TGFB1I1 and cancer: Du X et al. [21] identified that stromal HIC-5 was a predictive risk factor for lymph node metastasis in human esophageal squamous cell carcinoma (ESCC) and that cancer-associated fibroblasts (CAFs)-derived Hic-5 regulated ESCC cell migration and invasion by regulating cytokines and modifying the extracellular matrix (ECM).