This is a rare finding, present in only 5%–10% of patients with FTLD.10 11 It is possible to correlate different pathologies with particular clinical presentations.12 Semantic dementia is almost always associated with TDP-43 proteinopathy, while progressive non-fluent dysphasia can be associated with tau or TDP-43. The gene discussed is TARDBP; the disease is proteostasis deficiencies.