Although the mechanisms by which TMSB4X regulates the actin cytoskeleton in the epidermis and other experimental systems are not entirely understood, Lee et al. showed that TMSB4X regulates actin dynamics in the growth cone of neurons and the lamellipodia of neuroblastoma cells by controlling the distribution of G-actin (Lee et al., 2013). This evidence concerns the gene TMSB4X and neuroblastoma.